A DATA-DRIVEN APPROACH TO CONSTRUCT A MOLECULAR MAP OF TRYPANOSOMA CRUZI TO IDENTIFY DRUGS AND VACCINE TARGETS

A Data-Driven Approach to Construct a Molecular Map of Trypanosoma cruzi to Identify Drugs and Vaccine Targets

Chagas disease (CD) is endemic in large parts of Central and South America, as well as in Texas and the southern regions of the United States.Successful parasites, such as the causative agent of CD, Trypanosoma cruzi have adapted to specific hosts during their phylogenesis.In this work, we have assembled an interactive network of the complex relati

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Identification of the carotenoid cleavage dioxygenase genes and functional analysis reveal DoCCD1 is potentially involved in beta-ionone formation in Dendrobium officinale

The carotenoids are the most widely distributed secondary metabolites in plants and can be degraded by carotenoid cleavage dioxygenase (CCD) to form apocarotenoids including an important C13 compound beta-ionone.Volatile beta-ionone can confer the violet and woody fragrance to plant essential oils, flowers, fruits, and vegetables, which therefore h

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